NDLI: Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment

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Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment

Content Provider	Scilit
Author	Kołoczek, Przemysław Skórska-Stania, Agnieszka Cierniak, Agnieszka Sebastian, Victor Komarnicka, Urszula K. Płotek, Michał Kyzioł, Agnieszka
Copyright Year	2018
Description	Journal: European Journal of Pharmaceutics and Biopharmaceutics Novel half-sandwich ruthenium(II) complexes with aminomethyl(diphenyl)phosphine derived from fluoroloquinolones (RuPCp, RuPSf, RuPLm, RuPNr) were being investigated as alternatives to well-established metal-based chemotherapeutics. All compounds were characterized by elemental analysis, selected spectroscopic methods (i.e., absorption and fluorescence spectroscopy, ESI-MS, NMR, circular dichroizm), X-ray diffractometry, ICP-MS, and electrochemical techniques. To overcome low solubility, serious side effects connected with systemic cytotoxicity of ruthenium complexes, and acquiring the resistance of cancer cells, polymeric nanoformulations based on Pluronic P-123 micelles loaded with selected Ru(II) complexes were prepared and characterized. Resulting micelles (RuPCp_M, RuPNr_M) enabled efficient drug accumulation inside human lung adenocarcinoma (A549 tumor cell line), proved by confocal microscopy and ICP-MS analysis, allowing cytotoxic action. Studied complexes exhibited promising cytotoxicity in vitro with IC50 values significantly lower than the reference drug cisplatin. The fluorescence spectroscopic data (CT-DNA titration, cell staining in vitro) together with analysis of DNA fragmentation (pBR322 plasmid, comet assay) provided clear evidence for the interaction with DNA inducing apoptotic cell death.
Related Links	http://zaguan.unizar.es/record/79071/files/texto_completo.pdf
Ending Page	81
Page Count	13
Starting Page	69
ISSN	09396411
DOI	10.1016/j.ejpb.2018.04.016
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume Number	128
Language	English
Publisher	Elsevier BV
Publisher Date	2018-07-01
Access Restriction	Open
Subject Keyword	Journal: European Journal of Pharmaceutics and Biopharmaceutics Pharmacology and Pharmacy Arene Ruthenium(ii) Complexes Polymeric Micelles Anticancer Activity
Content Type	Text
Resource Type	Article
Subject	Medicine Biotechnology Pharmaceutical Science

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