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Identification of a calcium phosphoserine coordination network in an adhesive organo-apatitic bone cement system
| Content Provider | Scilit |
|---|---|
| Author | Kesseli, Fioleda P. Lauer, Caroline S. Baker, Ian Mirica, Katherine A. Citters, Douglas W. Van |
| Copyright Year | 2020 |
| Description | Journal: Acta Biomaterialia Calcium phosphate-based bone cements have been widely adopted in both orthopedic and dental applications. Phosphoserine (pSer), which has a natural role in biomineralization, has been identified to possess the functionality to react with calcium phosphate phases, such as tetracalcium phosphate (TTCP) and α-tricalcium phosphate (α-TCP), and form a uniquely adhesive cement. This study investigated the chemical composition and phase evolution of a heterogeneous calcium phosphate (56% TTCP and 15% α-TCP) and pSer cement system with respect to pH. The coordination network of calcium phosphoserine monohydrate was discovered as the predominant crystalline phase of this adhesive apatitic cement system. Furthermore, it was determined that pH has a significant effect on the reaction kinetics of the system, whereby a lower pH tends to accelerate the reaction rate and favor products with lower Ca/P ratios. These findings provide a better understanding of the reaction and products of this adhesive organo-ceramic cement, which can be compositionally tuned for broad applications in the orthopedic and dental spaces. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134197/pdf |
| Ending Page | 289 |
| Page Count | 10 |
| Starting Page | 280 |
| ISSN | 17427061 |
| e-ISSN | 18787568 |
| DOI | 10.1016/j.actbio.2020.01.007 |
| Journal | Acta Biomaterialia |
| Volume Number | 105 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2020-01-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Biomaterialia Calcium Phosphate Coordination Network |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology |
