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Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
| Content Provider | Scilit |
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| Author | Feigin, Valery L. Nichols, Emma Alam, Tahiya Bannick, Marlena S. Beghi, Ettore Blake, Natacha Culpepper, William J. Dorsey, E. Ray Elbaz, Alexis Ellenbogen, Richard G. Fisher, James L. Fitzmaurice, Christina Giussani, Giorgia Glennie, Linda James, Spencer L. Johnson, Catherine Owens Kassebaum, Nicholas J. Logroscino, Giancarlo Marin, Benoît Mountjoy-Venning, W. Cliff Nguyen, Minh Ofori-Asenso, Richard Patel, Anoop P. Piccininni, Marco Roth, Gregory A. Steiner, Timothy J. Stovner, Lars Jacob Szoeke, Cassandra E. I. Theadom, Alice Vollset, Stein Emil Wallin, Mitchell Taylor Wright, Claire Zunt, Joseph Raymond Abbasi, Nooshin Abd-Allah, Foad Abdelalim, Ahmed Abdollahpour, Ibrahim Aboyans, Victor Abraha, Haftom Niguse Acharya, Dilaram Adamu, Abdu A. Adebayo, Oladimeji M. Adeoye, Abiodun Moshood Adsuar, Jose C. Afarideh, Mohsen Agrawal, Sutapa Ahmadi, Alireza Ahmed, Muktar Beshir Aichour, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Akinyemi, Rufus Olusola Akseer, Nadia Al-Eyadhy, Ayman Salman, Rustam Al-Shahi Alahdab, Fares Alene, Kefyalew Addis Aljunid, Syed Mohamed Altirkawi, Khalid Alvis-Guzman, Nelson Anber, Nahla Hamed Antonio, Carl Abelardo T. Arabloo, Jalal Aremu, Olatunde Ärnlöv, Johan Asayesh, Hamid Asghar, Rana Jawad Atalay, Hagos Tasew Awasthi, Ashish Quintanilla, Beatriz Paulina Ayala Ayuk, Tambe B. Badawi, Alaa Banach, Maciej Banoub, Joseph Adel Mattar Barboza, Miguel A. Barker-Collo, Suzanne Lyn Bärnighausen, Till Winfried Baune, Bernhard T. Bedi, Neeraj Behzadifar, Masoud Behzadifar, Meysam Béjot, Yannick Bekele, Bayu Begashaw Belachew, Abate Bekele Bennett, Derrick A. Bensenor, Isabela M. Berhane, Adugnaw Beuran, Mircea Bhattacharyya, Krittika Bhutta, Zulfiqar A. Biadgo, Belete Bijani, Ali Bililign, Nigus Sayeed, Muhammad Shahdaat Bin Blazes, Christopher Kynrint Brayne, Carol Butt, Zahid A. Campos-Nonato, Ismael R. Cantu-Brito, Carlos Car, Mate Cárdenas, Rosario Carrero, Juan J. Carvalho, Félix Castañeda-Orjuela, Carlos A. Castro, Franz Catalá-López, Ferrán Cerin, Ester Chaiah, Yazan Chang, Jung-Chen Chatziralli, Irini Chiang, Peggy Pei-Chia Christensen, Hanne Christopher, Devasahayam J. Cooper, Cyrus Cortesi, Paolo Angelo Costa, Vera M. Criqui, Michael H. Crowe, Christopher Stephen Damasceno, Albertino Antonio Moura Daryani, Ahmad Cruz-Góngora, Vanessa De la Hoz, Fernando Pio De la Leo, Diego De Demoz, Gebre Teklemariam Deribe, Kebede Dharmaratne, Samath Dhamminda Diaz, Daniel Dinberu, Mesfin Tadese Djalalinia, Shirin Doku, David Teye Dubey, Manisha Dubljanin, Eleonora Duken, Eyasu Ejeta Edvardsson, David El-Khatib, Ziad Endres, Matthias Endries, Aman Yesuf Eskandarieh, Sharareh Esteghamati, Alireza Esteghamati, Sadaf Farhadi, Farzaneh Faro, Andre Farzadfar, Farshad Farzaei, Mohammad Hosein Fatima, Batool Fereshtehnejad, Seyed-Mohammad Fernandes, Eduarda Feyissa, Garumma Tolu Filip, Irina Fischer, Florian Fukumoto, Takeshi Ganji, Morsaleh Gankpe, Fortune Gbetoho Garcia-Gordillo, Miguel A. Gebre, Abadi Kahsu Gebremichael, Teklu Gebrehiwo Gelaw, Belayneh K. Geleijnse, Johanna M. Geremew, Demeke Gezae, Kebede Embaye Ghasemi-Kasman, Maryam Gidey, Mahari Y. Gill, Paramjit Singh Gill, Tiffany K. Girma, Efrata Tufa Gnedovskaya, Elena V. 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Polinder, Suzanne Postma, Maarten J. Poulton, Richie Poustchi, Hossein Prakash, Swayam Prakash, V. Qorbani, Mostafa Radfar, Amir Rafay, Anwar Rafiei, Alireza Rahim, Fakher Rahimi-Movaghar, Vafa Rahman, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Muhammad Aziz Rajati, Fatemeh Ram, Usha Ranta, Anna Rawaf, David Laith Rawaf, Salman Reinig, Nickolas Reis, Cesar Renzaho, Andre M. N. Resnikoff, Serge Rezaeian, Shahab Rezai, Mohammad Sadegh González, Carlos Miguel Rios Roberts, Nicholas L. S. Roever, Leonardo Ronfani, Luca Roro, Elias Merdassa Roshandel, Gholamreza Rostami, Ali Sabbagh, Parisa Sacco, Ralph L. Sachdev, Perminder S. Saddik, Basema Safari, Hosein Safari-Faramani, Roya Safi, Sare Safiri, Saeid Sagar, Rajesh Sahathevan, Ramesh Sahebkar, Amirhossein Sahraian, Mohammad Ali Salamati, Payman Zahabi, Saleh Salehi Salimi, Yahya Samy, Abdallah M. Sanabria, Juan Santos, Itamar S. Milicevic, Milena M. Santric Sarrafzadegan, Nizal Sartorius, Benn Sarvi, Shahabeddin Sathian, Brijesh Satpathy, Maheswar Sawant, Arundhati R. Sawhney, Monika Schneider, Ione J. C. Schöttker, Ben Schwebel, David C. Seedat, Soraya Sepanlou, Sadaf G. Shabaninejad, Hosein Shafieesabet, Azadeh Shaikh, Masood Ali Shakir, Raad A. Shams-Beyranvand, Mehran Shamsizadeh, Morteza Sharif, Mehdi Sharif-Alhoseini, Mahdi She, Jun Sheikh, Aziz Sheth, Kevin N. Shigematsu, Mika Shiri, Rahman Shirkoohi, Reza Shiue, Ivy Siabani, Soraya Siddiqi, Tariq J. Sigfusdottir, Inga Dora Sigurvinsdottir, Rannveig Silberberg, Donald H. Silva, João Pedro Silveira, Dayane Gabriele Alves Singh, Jasvinder A. Sinha, Dhirendra Narain Skiadaresi, Eirini Smith, Mari Sobaih, Badr Hasan Sobhani, Soheila Soofi, Moslem Soyiri, Ireneous N. Sposato, Luciano A. Stein, Dan J. Stein, Murray B. Stokes, Mark A. Sufiyan, Mu'awiyyah Babale Sykes, Bryan L. 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Yip, Paul Yisma, Engida Yonemoto, Naohiro Yousefifard, Mahmoud Yu, Chuanhua Zaidi, Zoubida Zaman, Sojib Bin Zamani, Mohammad Zandian, Hamed Zare, Zohreh Zhang, Yunquan Zodpey, Sanjay Naghavi, Mohsen Murray, Christopher J. L. Vos, Theo |
| Copyright Year | 2019 |
| Description | Journal: The Lancet Neurology |
| Abstract | Summary Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding Bill & Melinda Gates Foundation. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459001/pdf http://www.thelancet.com/article/S147444221830499X/pdf |
| Ending Page | 480 |
| Page Count | 22 |
| Starting Page | 459 |
| ISSN | 14744422 |
| DOI | 10.1016/s1474-4422%2818%2930499-x |
| Journal | The Lancet Neurology |
| Issue Number | 5 |
| Volume Number | 18 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-03-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Lancet Neurology Clinical Neurology Neurological Disorders Alzheimer's Disease Idiopathic Epilepsy Multiple Sclerosis Type Headache Tension Type |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) |
