Loading...
Please wait, while we are loading the content...
Similar Documents
MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway
| Content Provider | Scilit |
|---|---|
| Author | Sang, Wei Wang, Ying Zhang, Cong Zhang, Dianzheng Sun, Cai Niu, Mingshan Zhang, Zhe Wei, Xiangyu Pan, Bin Chen, Wei Yan, Dongmei Zeng, Lingyu Loughran, Thomas P. Xu, Kailin |
| Copyright Year | 2016 |
| Description | Journal: Immunology Letters MiR-150, a major modulator negatively regulating the development and differentiation of various immune cells, is widely involved in orchestrating inflammation. In transplantation immunity, miR-150 can effectively induce immune tolerance, although the underlying mechanisms have not been fully elucidated. In the current study, we found that miR-150 is elevated after blocking CD28/B7 co-stimulatory signaling pathway and impaired IL-2 production by targeting ARRB2. Further investigation suggested that miR-150 not only repressed the level of ARRB2/PDE4 directly but also prevented AKT/ARRB2/PDE4 trimer recruitment into the lipid raft by inhibiting the activities of PI3K and AKT through the cAMP-PKA-Csk signaling pathway. This leads to the interruption of cAMP degradation and subsequently results in inhibition of the NF-kB pathway and reduced production of both IL-2 and TNF. In conclusion, our study demonstrated that miR-150 can effectively prevent CD28/B7 co-stimulatory signaling transduction, decrease production of inflammatory cytokines, such as IL-2 and TNF, and elicit the induction of immune tolerance. Therefore, miR-150 could become a novel potential therapeutic target in transplantation immunology. |
| Related Links | http://europepmc.org/articles/pmc4846526?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846526/pdf |
| ISSN | 01652478 |
| e-ISSN | 18790542 |
| DOI | 10.1016/j.imlet.2015.11.001 |
| Journal | Immunology Letters |
| Volume Number | 172 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Immunology Letters Biochemistry and Molecular Biology Cd28/b7 Co-stimulatory Signaling Pathway Inflammatory Cytokine T Cell |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
