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Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2
| Content Provider | Scilit |
|---|---|
| Author | Paschos, Georgios K. Tang, Soon Yew Theken, Katherine N. Li, Xuanwen Verginadis, Ioannis Lekkas, Damien Herman, Lindsay Yan, Weili Lawson, John Gerald, Garret A. Fitz |
| Copyright Year | 2018 |
| Description | Journal: Cell Reports Summary Previous studies using genetic mouse models have implicated COX-2 in the browning of white adipose tissues (WATs) in mice during cold exposure. However, COX-2 is important during development, and conventional knockouts (KOs) exhibit many defects, conditioned by genetic background. Similarly, the physiological relevance of transgenic overexpression of COX-2 is questionable. In the present study, we utilized mice in which COX-2 was deleted postnatally, bypassing the consequences of enzyme deficiency during development. Despite activation of thermogenesis and browning of inguinal WAT, cold exposure failed to increase COX-2 expression in the adipose tissues of mice with different genetic backgrounds, and the body temperature response to cold was unaltered in postnatal global COX-2 KOs. Selective disruption of COX-2 in adipose tissues also failed detectably to impact systemic prostaglandin biosynthesis. Browning of inguinal WATs induced by exposure to cold is independent of adipose tissue COX-2. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118132/pdf http://www.cell.com/article/S221112471831009X/pdf |
| Ending Page | 814 |
| Page Count | 6 |
| Starting Page | 809 |
| ISSN | 22111247 |
| e-ISSN | 22111247 |
| DOI | 10.1016/j.celrep.2018.06.082 |
| Journal | Cell Reports |
| Issue Number | 4 |
| Volume Number | 24 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Reports Endocrinology and Metabolism Adipose Tissues Cold Exposure |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
