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Antenatal Betamethasone: A Prolonged Time Interval from Administration to Delivery Is Associated with an Increased Incidence of Severe Intraventricular Hemorrhage in Infants Born before 28 Weeks Gestation
| Content Provider | Scilit |
|---|---|
| Author | Liebowitz, Melissa Clyman, Ronald I. |
| Copyright Year | 2016 |
| Description | Journal: The Journal of pediatrics Objective To examine the effects of antenatal steroids on severe intraventricular hemorrhage (IVH) in infants born during the IVH vulnerable period (<28 weeks gestational age) and to evaluate rates of IVH correlated with the time interval between treatment or retreatment and birth. Study design A total of 429 infants (<28 weeks gestation), who delivered ≥24 hours after the first betamethasone (BMZ) course (2 doses), were divided into groups based on the interval between the first course of BMZ and delivery: <10 days or ≥10 days. The primary outcome was severe IVH. Multiple regression analyses were performed to adjust for potential confounders. Results Three hundred ninety-two infants delivered after a single BMZ course (312 delivered <10 days; 80 ≥10 days). The incidence of severe IVH was 17% for infants delivered ≥10 days and 7% for those delivered <10 days after a single BMZ course (aOR 4.16; 95% CI 1.59-10.87, P = .004); 37 infants (born ≥10 days from the first BMZ course) received a second/rescue BMZ course. The incidence of severe IVH among infants receiving a second/rescue course was 8%, which was similar to the incidence among infants born <10 days (aOR 1.7; 95% CI 0.41-6.6, P = .48). Conclusions In infants born before 28 weeks gestation, delivery ≥10 days from the first BMZ course is associated with a higher incidence of severe IVH; a second/rescue course may reverse this effect. |
| Related Links | https://manuscript.elsevier.com/S0022347616305236/pdf/S0022347616305236.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037021/pdf http://www.jpeds.com/article/S0022347616305236/pdf |
| ISSN | 00223476 |
| e-ISSN | 10976833 |
| DOI | 10.1016/j.jpeds.2016.07.002 |
| Journal | The Journal of pediatrics |
| Volume Number | 177 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-08-08 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of pediatrics Pediatrics and Child Health Intracranial Hemorrhage Bronchopulmonary Dysplasia Intraventricular Hemorrhage Necrotizing Enterocolitis Randomized Controlled Trials Respiratory Distress Syndrome Retinopathy of Prematurity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
