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Postoperative Enteral Nutrition Guidelines Reduce the Risk of Intestinal Failure–Associated Liver Disease in Surgical Infants
| Content Provider | Scilit |
|---|---|
| Author | Shores, Darla R. Alaish, Samuel M. Aucott, Susan W. Bullard, Janine E. Haney, Courtney Tymann, Heidi Nonyane, Bareng A. S. Schwarz, Kathleen B. |
| Copyright Year | 2018 |
| Description | Journal: The Journal of pediatrics To assess the effectiveness of postoperative feeding guidelines in reducing the incidence and severity of intestinal failure–associated liver disease (IFALD) among infants. Two cohorts of infants 2 mg/dL) and severity (DB >5 mg/dL for moderate-severe). Multiple logistic regression was used to determine the odds of developing IFALD. Other outcomes were time to reach 50% and 100% goal calories from enteral nutrition and the incidence of necrotizing enterocolitis after feeding. The incidence of IFALD decreased from 71% to 51% (P = .031), and median peak DB decreased from 5.7 to 2.4 mg/dL (P = .001). After adjusting for diagnosis and prematurity, the odds of developing IFALD of any severity were reduced by 60% (OR 0.40, 95% CI 0.20-0.85), and the odds of developing moderate-to-severe IFALD were reduced by 72% (OR 0.28, 95% CI 0.13-0.58) with guideline use. Time to reach 50% enteral nutrition decreased from a median of 10 to 6 days (P = .020) and time to reach 100% enteral nutrition decreased from 35 to 21 days (P = .035) with guideline use. The incidence of necrotizing enterocolitis after initiating enteral nutrition did not change (5% vs 9%, P = .346). Implementation of feeding guidelines reduced time to reach feeding goals, significantly reducing IFALD incidence and severity. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869117/pdf http://www.jpeds.com/article/S0022347617316141/pdf |
| ISSN | 00223476 |
| e-ISSN | 10976833 |
| DOI | 10.1016/j.jpeds.2017.11.058 |
| Journal | The Journal of pediatrics |
| Volume Number | 195 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of pediatrics Pediatrics and Child Health Short Bowel Syndrome Necrotizing Enterocolitis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
