Neuroprotective effects of LMW and HMW FGF2 against amyloid beta toxicity in primary cultured hippocampal neurons

Content Provider	Scilit
Author	Cheng, Yong Li, Zhaojin Kardami, Elissavet Loh, Y. Peng
Copyright Year	2016
Description	Journal: Neuroscience Letters Basic Fibroblast growth factor (FGF2) is important in development and maintenance of central nervous system function. Studies have demonstrated that low molecular weight (LMW) FGF2 is a neuroprotective factor against various insults in vivo and in vitro. In the present study we investigated the neuroprotective effects of high molecular weight (HMW) and LMW FGF2 against amyloid beta-induced neurotoxicity. The results showed that both LMW and HMW FGF2 attenuated the amyloid beta toxicity in the primary cultured hippocampal neurons as measured by WST and LDH release assay. Moreover, the analysis suggested that HMW FGF2 had stronger neuroprotective effect than LMW FGF2. We then demonstrated that LMW and HMW FGF2 activated the ERK and AKT signaling pathways in a similar way. Furthermore, using the ERK inhibitor and AKT inhibitor, we found that the AKT signaling but not ERK signaling pathway was required for the neuroprotective effects of FGF2. Taken together, these results showed the neuroprotective effects of different forms of FGF2 in an AD model and the mechanism underlying the neuroprotection.
Related Links	http://europepmc.org/articles/pmc5042867?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042867/pdf
Ending Page	113
Page Count	5
Starting Page	109
ISSN	03043940
e-ISSN	18727972
DOI	10.1016/j.neulet.2016.08.031
Journal	Neuroscience Letters
Volume Number	632
Language	English
Publisher	Elsevier BV
Publisher Date	2016-10-01
Access Restriction	Open
Subject Keyword	Journal: Neuroscience Letters Biochemistry and Molecular Biology Amyloid Beta Hmw Fgf2 Hippocampal Neuron Lmw Fgf2
Content Type	Text
Resource Type	Article
Subject	Neuroscience