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Pannexin1 as mediator of inflammation and cell death
| Content Provider | Scilit |
|---|---|
| Author | Yanguas, Sara Crespo Willebrords, Joost Johnstone, Scott R. Maes, Michaël Decrock, Elke Bock, Marijke De Leybaert, Luc Cogliati, Bruno Vinken, Mathieu |
| Copyright Year | 2017 |
| Description | Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693326/pdf |
| Ending Page | 61 |
| Page Count | 11 |
| Starting Page | 51 |
| ISSN | 01674889 |
| e-ISSN | 18792596 |
| DOI | 10.1016/j.bbamcr.2016.10.006 |
| Journal | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research |
| Issue Number | 1 |
| Volume Number | 1864 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Biochemistry and Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
