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Freeze-casting porous chitosan ureteral stents for improved drainage
| Content Provider | Scilit |
|---|---|
| Author | Yin, Kaiyang Divakar, Prajan Wegst, Ulrike G. K. |
| Copyright Year | 2018 |
| Description | Journal: Acta Biomaterialia As a new strategy for improved urinary drainage in parallel to the potential for additional functions such as drug release and self-removal, highly porous chitosan stents are manufactured by radial, bi-directional freeze-casting. Inserting the porous stent in a silicone tube to emulate its placement in the ureter shows that it is shape conforming and remains safely positioned in place, also during flow tests, including those performed in a peristaltic pump. Cyclic compression tests on fully-hydrated porous stents reveal high stent resilience and close to full elastic recovery upon unloading. The drainage performance of the chitosan stent is evaluated, using effective viscosity in addition to volumetric flow and flux; the porous stent’s performance is compared to that of the straight portion of a commercial 8 Fr double-J stent which possesses, in its otherwise solid tube wall, regularly spaced holes along its length. Both the porous and the 8 Fr stent show higher effective viscosities when tested in the silicone tube. The performance of the porous stent improves considerably more (47.5%) than that of the 8 Fr stent (30.6%) upon removal from the tube, illustrating the effectiveness of the radially aligned porosity for drainage. We conclude that the newly-developed porous chitosan ureteral stent merits further in vitro and in vivo assessment of its promise as an alternative and complement to currently available medical devices. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864386/pdf |
| Ending Page | 241 |
| Page Count | 11 |
| Starting Page | 231 |
| ISSN | 17427061 |
| e-ISSN | 18787568 |
| DOI | 10.1016/j.actbio.2018.11.005 |
| Journal | Acta Biomaterialia |
| Volume Number | 84 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-11-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Biomaterialia Bi-directional Freezing |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology |
