A compact, low-cost, quantitative and multiplexed fluorescence detection platform for point-of-care applications

Content Provider	Scilit
Author	Obahiagbon, Uwadiae Smith, Joseph T. Zhu, Meilin Katchman, Benjamin A. Arafa, Hany Anderson, Karen S. Christen, Jennifer M. Blain
Copyright Year	2018
Description	Journal: Biosensors and Bioelectronics An effective method of combating infectious diseases is the deployment of hand-held devices at the point-of-care (POC) for screening or self-monitoring applications. There is a need for very sensitive, low-cost and quantitative diagnostic devices. In this study, we present a low-cost, multiplexed fluorescence detection platform that has a high sensitivity and wide dynamic range. Our system features inexpensive 3 × 3 mm interference filters with a high stopband rejection, sharp transition edges, and greater than 90% transmission in the passband. In addition to the filters, we improve signal-to-noise ratio by leveraging time for accuracy using a charge-integration-based readout. The fluorescence sensing platform provides a sensitivity to photon flux of
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095205/pdf https://www.sciencedirect.com/science/article/pii/S0956566318302562/pdfft?md5=b1b86a985a6e8d8e1d14c1ae260e60dd&pid=1-s2.0-S0956566318302562-main.pdf
Ending Page	160
Page Count	8
Starting Page	153
ISSN	09565663
e-ISSN	18734235
DOI	10.1016/j.bios.2018.04.002
Journal	Biosensors and Bioelectronics
Volume Number	117
Language	English
Publisher	Elsevier BV
Publisher Date	2018-04-04
Access Restriction	Open
Subject Keyword	Journal: Biosensors and Bioelectronics Limit of Detection
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry