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The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors
| Content Provider | Scilit |
|---|---|
| Author | Smith, Jeffrey S. Rajagopal, Sudarshan |
| Copyright Year | 2016 |
| Description | Journal: Journal of Biological Chemistry The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for βarrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling. |
| Related Links | http://www.jbc.org/content/291/17/8969.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861465/pdf http://www.jbc.org/article/S0021925820410981/pdf |
| Ending Page | 8977 |
| Page Count | 9 |
| Starting Page | 8969 |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| DOI | 10.1074/jbc.r115.713313 |
| Journal | Journal of Biological Chemistry |
| Issue Number | 17 |
| Volume Number | 291 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biological Chemistry Cell Biology 7-helix Receptor G Protein-coupled Receptor (gpcr) Receptor Desensitization Receptor Endocytosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
