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Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia
| Content Provider | Scilit |
|---|---|
| Author | Wright, David Poon, Liona C. Rolnik, Daniel Lorber Syngelaki, Argyro Delgado, Juan Luis Vojtassakova, Denisa de Alvarado, Mercedes Kapeti, Evgenia Rehal, Anoop Pazos, Andrea Carbone, Ilma Floriana Dutemeyer, Vivien Plasencia, Walter Papantoniou, Nikos Nicolaides, Kypros H. |
| Copyright Year | 2017 |
| Description | Journal: American Journal of Obstetrics and Gynecology To examine the influence of compliance on the beneficial effect of aspirin in prevention of preterm preeclampsia in the Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial.This was a secondary analysis of data from the ASPRE trial. In this multicenter-study women with singleton pregnancies had screening by means of an algorithm that combines maternal factors and biomarkers (mean arterial pressure, uterine-artery pulsatility index, and maternal serum pregnancy-associated plasma protein A and placental growth factor) at 11-13 weeks' gestation. Those with an estimated risk for preterm preeclampsia of >1 in 100 were invited to participate in a double-blind trial of aspirin (150 mg per day) vs. placebo from 11 to 14 until 36 weeks' gestation. Preterm preeclampsia with delivery at 90%, after adjustment for the estimated risk of preterm preeclampsia at screening and the participating center. The choice of cut-off of 90% was based on an exploratory analysis of the treatment effect. Logistic regression analysis was used to investigate predictors of compliance >90% among maternal characteristics and medical history.Preterm preeclampsia occurred in 5/555 (0.9%) participants in the aspirin group with compliance ≥90%, in 8/243 (3.3%) of participants in the aspirin group with compliance 90% and 0.59 (95% confidence interval, 0.23 to 1.53) for compliance <90%. Compliance was positively associated with family history of preeclampsia and negatively associated with smoking, maternal age <25 years, Afro-Caribbean and South Asian racial origin, and history of preeclampsia in a previous pregnancy.The beneficial effect of aspirin in the prevention of preterm preeclampsia appears to depend on compliance. |
| Related Links | https://kclpure.kcl.ac.uk/portal/files/77665877/ASPRE_trial_influence_of_WRIGHT_Accepted31August2017_GREEN_AAM.pdf |
| Ending Page | 685.e5 |
| Page Count | 5 |
| Starting Page | 685.e1 |
| ISSN | 00029378 |
| e-ISSN | 10976868 |
| DOI | 10.1016/j.ajog.2017.08.110 |
| Journal | American Journal of Obstetrics and Gynecology |
| Issue Number | 6 |
| Volume Number | 217 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Obstetrics and Gynecology Obstetrics and Gynecology First Trimester Screening Mean Arterial Blood Pressure Placental Growth Factor Pregnancy Associated Plasma Protein-a Pyramid of Pregnancy Care Uterine Artery Doppler |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
