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Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment
| Content Provider | Scilit |
|---|---|
| Author | He, Pengbo Li, Qiang |
| Copyright Year | 2021 |
| Description | Journal: Physica Medica Purpose A novel variable cycle-based respiratory guidance method was proposed to synchronize the patterns between patients' breathing and the magnetic excitation of synchrotron under the mode of full-energy depth scanning beam delivery, in order to improve the treatment precision and efficiency for carbon ion therapy. Methods Audio-visual biofeedback system with variable cycle-based respiratory guidance method was developed. We enrolled 6 healthy volunteers and a simulation study of the fixed cycle-based and variable cycle-based respiratory guidance with three treatment fractions was performed. A total of 72 breathing curves were collected for 4D dose calculations with three 4DCT datasets of lung tumor cases. Target dose coverage (D95: the percent dose covering 95% of the target), dose homogeneity (D5-D95), and treatment time were analyzed. The Wilcoxon signed-rank test was used for statistical difference analysis, and p < 0.05 was considered significant. Results With the variable cycle-based respiratory guidance method, the breath hold phase of breathing curve could be synchronized with the synchrotron flat-top phase over time. The dose homogeneity was improved by factors of 1.94–2.92 compared to the fixed cycle-based respiratory guidance maneuvers alone or in combination with gating technique. Moreover, the treatment efficiency increased by 11–23%, depending on the duty cycle settings of the gating window. Conclusions The proposed variable cycle-based respiratory guidance method could improve both the treatment efficiency and precision under the mode of the full-energy depth scanning beam delivery for synchrotron-based carbon ion therapy. |
| Related Links | http://www.physicamedica.com/article/S1120179721002258/pdf |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2021.06.005 |
| Journal | Physica Medica |
| Volume Number | 87 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2021-06-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Radiology, Nuclear Medicine and Imaging Carbon Ion Therapy 4d Dose Calculation Respiratory Guidance Synchrotron Magnetic Excitation Pattern |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
