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Mechanical properties and failure analysis of visible light crosslinked alginate-based tissue sealants
| Content Provider | Scilit |
|---|---|
| Author | Charron, Patrick N. Fenn, Spencer L. Poniz, Alex Floreani, Rachael |
| Copyright Year | 2016 |
| Description | Journal: Journal of the mechanical behavior of biomedical materials Moderate to weak mechanical properties limit the use of naturally-derived tissue sealants for dynamic medical applications, e.g., sealing a lung leak. To overcome these limitations, we developed visible-light crosslinked alginate-based hydrogels, as either non-adhesive methacrylated alginate (Alg-MA) hydrogel controls, or oxidized Alg-MA (Alg-MA-Ox) tissue adhesive tissue sealants, which form covalent bonds with extracellular matrix (ECM) proteins. Our study investigated the potential for visible-light crosslinked Alg-MA-Ox hydrogels to serve as effective surgical tissue sealants for dynamic in vivo systems. The Alg-MA-Ox hydrogels were designed to be an injectable system, curable in situ. Burst pressure experiments were conducted on a custom-fabricated burst pressure device using constant air flow; burst pressure properties and adhesion characteristics correlated with the degrees of methacrylation and oxidation. In summary, visible light crosslinked Alg-MA-Ox hydrogel tissue sealants form effective seals over critically-sized defects, and maintain pressures up to 50mm Hg. |
| Related Links | https://manuscript.elsevier.com/S1751616116000412/pdf/S1751616116000412.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860120/pdf |
| Ending Page | 321 |
| Page Count | 8 |
| Starting Page | 314 |
| ISSN | 17516161 |
| e-ISSN | 18780180 |
| DOI | 10.1016/j.jmbbm.2016.02.003 |
| Journal | Journal of the mechanical behavior of biomedical materials |
| Volume Number | 59 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of the mechanical behavior of biomedical materials Visible Light Crosslinking |
| Content Type | Text |
| Resource Type | Article |
| Subject | Mechanics of Materials Biomaterials Biomedical Engineering |
