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The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function
| Content Provider | Scilit |
|---|---|
| Author | Pennington, Edward Ross Funai, Katsuhiko Brown, David A. Shaikh, Saame Raza |
| Copyright Year | 2019 |
| Description | Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL concentration and acyl chain composition would presumably disrupt mitochondrial inner membrane biophysical organization. However, it remains unclear in the literature as to which is the key regulator of mitochondrial membrane biophysical properties. We review the literature to discriminate the effects of CL concentration and acyl chain composition on mitochondrial membrane organization. A widely applicable theme emerges across several pathologies, including cardiovascular diseases, diabetes, Barth syndrome, and neurodegenerative ailments. The loss of CL, often accompanied by increased levels of lyso-CLs, impairs mitochondrial inner membrane organization. Modest remodeling of CL acyl chains is not a major driver of impairments and only in cases of extreme remodeling is there an influence on membrane properties. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482085/pdf |
| Ending Page | 1052 |
| Page Count | 14 |
| Starting Page | 1039 |
| ISSN | 13881981 |
| e-ISSN | 18792618 |
| DOI | 10.1016/j.bbalip.2019.03.012 |
| Journal | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids |
| Issue Number | 7 |
| Volume Number | 1864 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-04-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Mitochondrial Structure-function Cardiolipin Content Acyl Chain Remodeling |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
