Loading...
Please wait, while we are loading the content...
Similar Documents
A nested phosphorus and proton coil array for brain magnetic resonance imaging and spectroscopy
| Content Provider | Scilit |
|---|---|
| Author | Brown, Ryan Lakshmanan, Karthik Madelin, Guillaume Parasoglou, Prodromos |
| Copyright Year | 2016 |
| Description | Journal: NeuroImage A dual-nuclei radiofrequency coil array was constructed for phosphorus and proton magnetic resonance imaging and spectroscopy of the human brain at 7T. An eight-channel transceive degenerate birdcage phosphorus module was implemented to provide whole-brain coverage and significant sensitivity improvement over a standard dual-tuned loop coil. A nested eight-channel proton module provided adequate sensitivity for anatomical localization without substantially sacrificing performance on the phosphorus module. The developed array enabled phosphorus spectroscopy, a saturation transfer technique to calculate the global creatine kinase forward reaction rate, and single-metabolite whole-brain imaging with 1.4cm nominal isotropic resolution in 15min (2.3cm actual resolution), while additionally enabling 1mm isotropic proton imaging. This study demonstrates that a multi-channel array can be utilized for phosphorus and proton applications with improved coverage and/or sensitivity over traditional single-channel coils. The efficient multi-channel coil array, time-efficient pulse sequences, and the enhanced signal strength available at ultra-high fields can be combined to allow volumetric assessment of the brain and could provide new insights into the underlying energy metabolism impairment in several neurodegenerative conditions, such as Alzheimer's and Parkinson's diseases, as well as mental disorders such as schizophrenia. |
| Related Links | http://europepmc.org/articles/pmc4651763?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651763/pdf |
| Ending Page | 611 |
| Page Count | 10 |
| Starting Page | 602 |
| ISSN | 10538119 |
| DOI | 10.1016/j.neuroimage.2015.08.066 |
| Journal | NeuroImage |
| Volume Number | 124 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: NeuroImage Radiology, Nuclear Medicine and Imaging Creatine Kinase Reaction Degenerate Birdcage Dual-tuned Coil Floret Pulse Sequence Transceive Phased Array |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Cognitive Neuroscience |
