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Blood–brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury
| Content Provider | Scilit |
|---|---|
| Author | Bharadwaj, Vimala N. Rowe, Rachel Wu, Chen Anderson, Trent R. Lifshitz, Jonathan Adelson, P. David Kodibagkar, Vikram D. Stabenfeldt, Sarah E. |
| Copyright Year | 2018 |
| Description | Journal: Nanomedicine: Nanotechnology, Biology and Medicine Clinically, traumatic brain injury (TBI) results in complex heterogeneous pathology that cannot be recapitulated in single pre-clinical animal model. Therefore, we focused on evaluating utility of nanoparticle (NP)-based therapeutics following three diffuse-TBI models: mild-closed-head injury (mCHI), repetitive-mCHI and midline-fluid percussion injury (FPI). We hypothesized that NP accumulation after diffuse TBI correlates directly with blood-brain-barrier permeability. Mice received PEGylated-NP cocktail (20-500nm) (intravenously) after single- or repetitive-(1 impact/day, 5 consecutive days) CHI (immediately) and midline-FPI (1h, 3h and 6h). NPs circulated for 1h before perfusion/brain extraction. NP accumulation was analyzed using fluorescent microscopy in brain regions vulnerable to neuropathology. Minimal/no NP accumulation after mCHI/RmCHI was observed. In contrast, midline-FPI resulted in significant peak accumulation of up to 500nm NP at 3h post-injury compared to sham, 1h, and 6h groups in the cortex. Therefore, our study provides the groundwork for feasibility of NP-delivery based on NP-injection time and NP-size after mCHI/RmCHI and midline-FPI. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177306/pdf |
| Ending Page | 2166 |
| Page Count | 12 |
| Starting Page | 2155 |
| ISSN | 15499634 |
| e-ISSN | 15499642 |
| DOI | 10.1016/j.nano.2018.06.004 |
| Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
| Issue Number | 7 |
| Volume Number | 14 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanomedicine: Nanotechnology, Biology and Medicine Blood Brain Barrier Fluid Percussion Injury Mild Closed Head Injury Optimal Therapeutic Window Traumatic Brain Injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Molecular Medicine Bioengineering Biomedical Engineering Pharmaceutical Science |
