NDLI: Microstructure-based finite element model of left ventricle passive inflation

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Microstructure-based finite element model of left ventricle passive inflation

Content Provider	Scilit
Author	Xi, Ce Kassab, Ghassan S. Lee, Lik Chuan
Copyright Year	2019
Description	Journal: Acta biomaterialia Isolating the role(s) of microstructural pathological features in affecting diastolic filling is important in developing targeted treatments for heart diseases. We developed a microstructure-based constitutive model of the myocardium and implemented it in an efficient open-source finite element modeling framework to simulate passive inflation of the left ventricle (LV) in a representative 3D geometry based on experimentally measured muscle fiber architecture. The constitutive model was calibrated using previous tissue-level biaxial mechanical test data derived from the canine heart and validated with independent sets of measurements made at both the isolated constituent and organ level. Using the validated model, we investigated the load taken up by each tissue constituent and their effects on LV passive inflation. The model predicts that the LV compliance is sensitive to the collagen ultrastructure, specifically, the collagen fiber azimuthal angle with respect to the local muscle fiber direction and its waviness. The model also predicts that most of the load in the sub-epicardial and sub-endocardial regions is taken up, respectively, by the muscle fibers and collagen fiber network. This result suggests that normalizing LV passive stiffness by altering the collagen fiber network and myocyte stiffness is most effective when applied to the sub-endocardial and sub-epicardial regions, respectively. This finding may have implication for the development of new pharmaceutical treatments targeting individual cardiac tissue constituents to normalize LV filling function in heart diseases.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677579/pdf
Ending Page	253
Page Count	13
Starting Page	241
ISSN	17427061
e-ISSN	18787568
DOI	10.1016/j.actbio.2019.04.016
Journal	Acta biomaterialia
Volume Number	90
Language	English
Publisher	Elsevier BV
Publisher Date	2019-04-11
Access Restriction	Open
Subject Keyword	Journal: Acta biomaterialia Cardiac Mechanics Microstructural Constitutive Model Collagen Fiber Network Finite Element Modeling Left Ventricle
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology

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