Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury

Content Provider	Scilit
Author	Greer, Kisha Chen, Jiang Brickler, Thomas Gourdie, Robert Theus, Michelle H.
Copyright Year	2017
Description	Journal: Brain research bulletin Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated connexin 43 (Cx43) plays a key role in the cell cycle regulation and function of NSPCs and is modulated following TBI. Here, we demonstrate that Cx43 is up-regulated in the dentate gyrus following TBI and is expressed on vimentin-positive cells in the subgranular zone. To test the role of Cx43 on NSPCs, we exposed primary cultures to the α-connexin Carboxyl Terminal (αCT1) peptide which selectively modulates GJ-associated Cx43. Treatment with αCT1 substantially reduced proliferation and increased caspase 3/7 expression on NSPCs in a dose-dependent manner. αCT1 exposure also reduced overall expression of Cx43 and phospho (p)-Serine368. These findings demonstrate that Cx43 positively regulates adult NPSCs; the modulation of which may influence changes in the dentate gyrus following TBI.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597487/pdf https://www.sciencedirect.com/science/article/pii/S0361923017302174/pdfft?md5=3242faa07263cf83c13c3dce4d179802&pid=1-s2.0-S0361923017302174-main.pdf
Ending Page	46
Page Count	9
Starting Page	38
ISSN	03619230
e-ISSN	18732747
DOI	10.1016/j.brainresbull.2017.06.016
Journal	Brain research bulletin
Volume Number	134
Language	English
Publisher	Elsevier BV
Publisher Date	2017-06-23
Access Restriction	Open
Subject Keyword	Journal: Brain research bulletin Traumatic Brain Injury Neural Stem Progenitor Cell Gap Junction
Content Type	Text
Resource Type	Article
Subject	Neuroscience