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Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B
| Content Provider | Scilit |
|---|---|
| Author | Mitra, Bidisha Thapa, Roshan J. Guo, Haitao Block, Timothy M. |
| Copyright Year | 2018 |
| Description | Journal: Antiviral Research Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily dependent upon and regulated by cellular (host) functions. These cellular functions can be generally placed in to two categories: (a) intrinsic host restriction factors and innate defenses, which must be evaded or repressed by the virus; and (b) gene products that provide functions necessary for the virus to complete its life cycle. Some of these functions may apply to all viruses, but some may be specific to HBV. In certain cases, the virus may depend upon the host function much more than does the host itself. Knowing which host functions regulate the different steps of a virus’ life cycle, can lead to new antiviral targets and help in developing novel treatment strategies, in addition to improving a fundamental understanding of viral pathogenesis. Therefore, in this review we will discuss known host factors which influence key steps of HBV life cycle, and further elucidate therapeutic interventions targeting host-HBV interactions. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193490/pdf |
| Ending Page | 198 |
| Page Count | 14 |
| Starting Page | 185 |
| ISSN | 01663542 |
| e-ISSN | 18729096 |
| DOI | 10.1016/j.antiviral.2018.08.014 |
| Journal | Antiviral Research |
| Volume Number | 158 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-08-24 |
| Access Restriction | Open |
| Subject Keyword | Journal: Antiviral Research Gastroenterology and Hepatology Hepatitis B Virus (hbv) Virus-host Interaction Antiviral Agents Direct Acting Antiviral Agents Host Targeting Agents |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Pharmacology |
