NDLI: Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney

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Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney

Content Provider	Scilit
Author	Gallegos, Thomas F. Kamei, Caramai N. Rohly, Michael Drummond, Iain A.
Copyright Year	2019
Description	Journal: Developmental biology The zebrafish kidney regenerates after injury by development of new nephrons from resident adult kidney stem cells. Although adult kidney progenitor cells have been characterized by transplantation and single cell RNA seq, signals that stimulate new nephron formation are not known. Here we demonstrate that fibroblast growth factors and FGF signaling is rapidly induced after kidney injury and that FGF signaling is required for recruitment of progenitor cells to sites of new nephron formation. Chemical or dominant negative blockade of Fgfr1 prevented formation of nephron progenitor cell aggregates after injury and during kidney development. Implantation of FGF soaked beads induced local aggregation of lhx1a:EGFP + kidney progenitor cells. Our results reveal a previously unexplored role for FGF signaling in recruitment of renal progenitors to sites of new nephron formation and suggest a role for FGF signaling in maintaining cell adhesion and cell polarity in newly forming kidney epithelia.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717540/pdf
Ending Page	51
Page Count	8
Starting Page	44
ISSN	00121606
e-ISSN	1095564X
DOI	10.1016/j.ydbio.2019.06.011
Journal	Developmental biology
Issue Number	1
Volume Number	454
Language	English
Publisher	Elsevier BV
Publisher Date	2019-10-01
Access Restriction	Open
Subject Keyword	Journal: Developmental biology Developmental Biology Adult Kidney Stem Cell Fibroblast Growth Factor
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Molecular Biology

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