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Oxidative pathways in the sickle cell and beyond

Content Provider	Scilit
Author	Alayash, Abdu I.
Copyright Year	2018
Description	Journal: Blood Cells, Molecules, and Diseases Polymerization of deoxy sickle cell hemoglobin (HbS) is well recognized as the primary event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs). RBCs are also subjected to continuous endogenous and exogenous oxidative onslaughts resulting in hemolytic rate increases which contribute to the evolution of vasculopathies associated with this disease. Compared to steady-state conditions, the occurrences of vaso-occlusive crises increase the levels of both RBC-derived microparticles as well as extracellular Hb in circulation. Common byproduct resulting from free Hb oxidation and from Hb-laden microparticles is heme (now recognized as damage associated molecular pattern (DAMP) molecule) which has been shown to initiate inflammatory responses. This review provides new insights into the interplay between microparticles, free Hb and heme focusing on Hb's pseudoperoxidative activity that drives RBC's cytosolic, membrane changes as well as oxidative toxicity towards the vascular system. Emerging antioxidative strategies that include the use of protein and heme scavengers in controlling Hb oxidative pathways are discussed.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696113/pdf
Ending Page	86
Page Count	9
Starting Page	78
ISSN	10799796
e-ISSN	10960961
DOI	10.1016/j.bcmd.2017.05.009
Journal	Blood Cells, Molecules, and Diseases
Volume Number	70
Language	English
Publisher	Elsevier BV
Publisher Date	2018-05-01
Access Restriction	Open
Subject Keyword	Journal: Blood Cells, Molecules, and Diseases Ferryl Hemoglobin Sickle Cell Hemoglobin
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Molecular Biology Molecular Medicine

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