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Tandem synthesis of 1-formyl-1,2,3-triazoles
| Content Provider | Scilit |
|---|---|
| Author | Fletcher, James T. Christensen, Joseph A. Villa, Eric M. |
| Copyright Year | 2017 |
| Description | Journal: Tetrahedron letters A tandem method for preparing 4-formyl-1,2,3-triazoles via a two-step one-pot acetal cleavage/CuAAC reaction was developed. Using this method, 4-formyl-1,2,3-triazole analogs with both electron-withdrawing and electron-donating substituents were prepared in good yield and purity. Expansion of this method to a three-step tandem reaction that incorporates an additional step of azide substitution was also successful, circumventing the need for organic azide isolation. This one-pot method, noteworthy in its simplicity and mild conditions, utilizes practical, readily available reactants and relies on protic solvent to promote acid-catalyzed acetal cleavage. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798646/pdf |
| Ending Page | 4454 |
| Page Count | 5 |
| Starting Page | 4450 |
| ISSN | 00404039 |
| DOI | 10.1016/j.tetlet.2017.10.023 |
| Journal | Tetrahedron letters |
| Issue Number | 47 |
| Volume Number | 58 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Tetrahedron letters Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Biochemistry |
