Effect of the electro-acupuncture on senile plaques and its formation in APP+/PS1+ double transgenic mice

Content Provider	Scilit
Author	Yang, Qinghua Zhu, Shujuan Xu, Jin Tang, Chenglin Wu, Kaihui Wu, Yanjun Wang, Yiying Sheng, Huajun
Copyright Year	2019
Description	Journal: Genes & Diseases Alzheimer's disease (AD) is a progressive neurodegenerative disease and its incidence will increase with age and is aggravating. The senile plaques (SPs) are one of three main pathological features in AD patients, which are formed by amyloid β-protein (Aβ) over-accumulation. β-amyloid precursor protein (APP), β-site APP cleavage (BACE1), and insulin degrading enzyme (IDE) proteins participate in the process of Aβ production and degradation. At present, the pathogenesis of AD is not yet clear and the current treatment methods can only relief the related symptoms of AD. The electro-acupuncture (EA) is a traditional Chinese medicine treatment combined the acupuncture and electrical stimulation and the treatment effect can also be controlled by transform the electrical frequency. Thus, in this experiment, we carried out behavioral test, immunohistochemistry (IHC), and Western Blot (WB) after different period treatments to the model mice by electro-acupuncturing “Baihui” and “Shenshu” acupoints in APP+/PS1+ double transgenic mice. It was found that the EA therapy can improve the ability of learning, memory and spatial exploration, and reduce the deposition of SPs in brain of AD model mice, and reduce the expressions of APP and BACE1, increase the expression of IDE protein. These results prompt that EA can effectively alleviate the pathological process of AD. We speculate that EA may play a comprehensive role in preventing the development of AD, considering the previous data.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997572/pdf
Ending Page	289
Page Count	8
Starting Page	282
ISSN	23523042
e-ISSN	23523042
DOI	10.1016/j.gendis.2018.06.002
Journal	Genes & Diseases
Issue Number	3
Volume Number	6
Language	English
Publisher	Elsevier BV
Publisher Date	2019-09-01
Access Restriction	Open
Subject Keyword	Journal: Genes & Diseases Alzheimer's Disease Amyloid Β-protein Electro-acupuncture Ad, Alzheimer's Disease Aβ, Amyloid Β-protein Sps, Senile Plaques Amyloid Precursor Protein, Bace1 Β－, Site App Cleavage Ide, Insulin Degrading Enzyme Ea, Electro-acupuncture Ihc, Immunohistochemistry Sod, Superoxide Dismutase Ach, Aetylcholine Chat, Aetylcholine Tansferase Ache, Cholinesterase
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Genetics (clinical)