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Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
| Content Provider | Scilit |
|---|---|
| Author | Iborra-Egea, Oriol Santiago-Vacas, Evelyn Yurista, Salva R. Lupón, Josep Packer, Milton Heymans, Stephane Zannad, Faiez Butler, Javed Pascual-Figal, Domingo Lax, Antonio Núñez, Julio de Boer, Rudolf A. Bayés-Genís, Antoni |
| Copyright Year | 2019 |
| Description | Journal: Jacc: Basic To Translational Science The mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger (NHE)-1 co-transporter with 94.7% accuracy, which was similar for diabetics and nondiabetics. Notably, direct NHE1 blockade by empagliflozin ameliorated cardiomyocyte cell death by restoring expression of X-linked inhibitor of apoptosis (XIAP) and baculoviral IAP repeat-containing protein 5 (BIRC5). These results were independent of diabetes mellitus comorbidity, suggesting that empagliflozin may emerge as a new treatment in HFrEF. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978551/pdf |
| Ending Page | 840 |
| Page Count | 10 |
| Starting Page | 831 |
| ISSN | 2452302X |
| DOI | 10.1016/j.jacbts.2019.07.010 |
| Journal | Jacc: Basic To Translational Science |
| Issue Number | 7 |
| Volume Number | 4 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-10-23 |
| Access Restriction | Open |
| Subject Keyword | Journal: Jacc: Basic To Translational Science Peripheral Vascular Disease Ann, Artificial Neural Network Dm, Diabetes Mellitus Hf, Heart Failure Hfref, Hf with Reduced Ejection Fraction Mi-hf, Post-infarct Heart Failure Nhe, Sodium-hydrogen Exchanger Rnaseq, Rna Sequencing Sglt2i, Sodium-glucose Co-transporter 2 Inhibitor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
