Loading...
Please wait, while we are loading the content...
Similar Documents
Removal of oxidatively generated DNA damage by overlapping repair pathways
| Content Provider | Scilit |
|---|---|
| Author | Shafirovich, Vladimir Geacintov, Nicholas E. |
| Copyright Year | 2017 |
| Description | Journal: Free Radical Biology & Medicine It is generally believed that the mammalian nucleotide excision repair pathway removes DNA helix-distorting bulky DNA lesions, while small non-bulky lesions are repaired by base excision repair (BER). However, recent work demonstrates that the oxidativly generated guanine oxidation products, spiroimininodihydantoin (Sp), 5-guanidinohydantoin (Gh), and certain intrastrand cross-linked lesions, are good substrates of NER and BER pathways that compete with one another in human cell extracts. The oxidation of guanine by peroxynitrite is known to generate 5-guanidino-4-nitroimidazole (NIm) which is structurally similar to Gh, except that the 4-nitro group in NIm is replaced by a keto group in Gh. However, unlike Gh, NIm is an excellent substrate of BER, but not of NER. These and other related results are reviewed and discussed in this article. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418118/pdf |
| Ending Page | 61 |
| Page Count | 9 |
| Starting Page | 53 |
| ISSN | 08915849 |
| e-ISSN | 18734596 |
| DOI | 10.1016/j.freeradbiomed.2016.10.507 |
| Journal | Free Radical Biology & Medicine |
| Volume Number | 107 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Free Radical Biology & Medicine Biochemistry and Molecular Biology Base Excision Repair Dna Damage Nucleotide Excision Repair Oxidative Stress Reactive Oxygen Species |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Biochemistry |
