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Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy
| Content Provider | Scilit |
|---|---|
| Author | Engels, Elette Corde, Stéphanie McKinnon, Sally Incerti, Sébastien Konstantinov, Konstantin Rosenfeld, Anatoly Tehei, Moeava Lerch, Michael Guatelli, Susanna |
| Copyright Year | 2016 |
| Description | Journal: Physica Medica Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with $Ta_{2}O_{5}$ nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. $Ta_{2}O_{5}$ NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by $Ta_{2}O_{5}$ NPs in MRT. Our study showed that NP shells enhance the physical dose depending microbeam energy and their location relative to a single microbeam. For monochromatic microbeam energies below ∼70keV, NP shells show highly localised dose enhancement due to the short range of associated secondary electrons. Low microbeam energies indicate better targeted treatment by allowing higher microbeam doses to be administered to tumours and better exploit the spatial fractionation related selectivity observed with MRT. For microbeam energies above ∼100keV, NP shells extend the physical dose enhancement due to longer-range secondary electrons. Again, with NPs selectively internalised, the local effectiveness of MRT is expected to increase in the tumour. Dose enhancement produced by the shell aggregate varied more significantly in the cell population, depending on its location, when compared to a homogeneous NP distribution. These combined simulation and experimental data provide first evidence for optimising MRT through the incorporation of newly observed $Ta_{2}O_{5}$ NP distributions within 9L cancer cells. |
| Related Links | https://ro.uow.edu.au/cgi/viewcontent.cgi?article=7313&context=eispapers http://www.physicamedica.com/article/S1120179716309759/pdf |
| Ending Page | 1861 |
| Page Count | 10 |
| Starting Page | 1852 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2016.10.024 |
| Journal | Physica Medica |
| Issue Number | 12 |
| Volume Number | 32 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-11-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Radiology, Nuclear Medicine and Imaging Microbeam Radiation Therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
