NDLI: Expansion of the genetic code via expansion of the genetic alphabet

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Expansion of the genetic code via expansion of the genetic alphabet

Content Provider	Scilit
Author	Dien, Vivian T. Morris, Sydney E. Karadeema, Rebekah J. Romesberg, Floyd E.
Copyright Year	2018
Description	Journal: Current opinion in chemical biology Current methods to expand the genetic code enable site-specific incorporation of non-canonical amino acids (ncAAs) into proteins in eukaryotic and prokaryotic cells. However, current methods are limited by the number of codons possible, their orthogonality, and possibly their effects on protein synthesis and folding. An alternative approach relies on unnatural base pairs to create a virtually unlimited number of genuinely new codons that are efficiently translated and highly orthogonal because they direct ncAA incorporation using forces other than the complementary hydrogen bonds employed by their natural counterparts. This review outlines progress and achievements made towards developing a functional unnatural base pair and its use to generate semi-synthetic organisms with an expanded genetic alphabet that serves as the basis of an expanded genetic code.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361380/pdf
Ending Page	202
Page Count	7
Starting Page	196
ISSN	13675931
e-ISSN	18790402
DOI	10.1016/j.cbpa.2018.08.009
Journal	Current opinion in chemical biology
Volume Number	46
Language	English
Publisher	Elsevier BV
Publisher Date	2018-09-08
Access Restriction	Open
Subject Keyword	Journal: Current opinion in chemical biology Biochemistry and Molecular Biology Genetic Alphabet
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Biochemistry

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