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KSHV strategies for host dsDNA sensing machinery
| Content Provider | Scilit |
|---|---|
| Author | Gao, Hang Song, Yanyan Liu, Chengrong Liang, Qiming |
| Copyright Year | 2016 |
| Description | Journal: Virologica Sinica The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi’s Sarcoma-associated Herpesvirus (KSHV) and their contributions to KSHV life cycles. Open image in new window |
| Related Links | https://link.springer.com/content/pdf/10.1007/s12250-016-3877-3.pdf |
| Ending Page | 471 |
| Page Count | 6 |
| Starting Page | 466 |
| ISSN | 16740769 |
| e-ISSN | 1995820X |
| DOI | 10.1007/s12250-016-3877-3 |
| Journal | Virologica Sinica |
| Issue Number | 6 |
| Volume Number | 31 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-12-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Virologica Sinica Kaposi's Sarcoma-associated Herpesvirus (kshv) Innate Immune Response Cyclic Gmp-amp Synthase (cgas) Evasion Strategies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Immunology Molecular Medicine |
