NDLI: In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter

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In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter

Content Provider	Scilit
Author	Fieremans, Els Burcaw, Lauren M. Lee, Hong-Hsi Lemberskiy, Gregory Veraart, Jelle Novikov, Dmitry S.
Copyright Year	2016
Description	Journal: NeuroImage The presence of micrometer-level restrictions leads to a decrease of diffusion coefficient with diffusion time. Here we investigate this effect in human white matter in vivo. We focus on a broad range of diffusion times, up to 600 ms, covering diffusion length scales up to about 30 μm. We perform stimulated echo diffusion tensor imaging on 5 healthy volunteers and observe a relatively weak time-dependence in diffusion transverse to major fiber tracts. Remarkably, we also find notable time-dependence in the longitudinal direction. Comparing models of diffusion in ordered, confined and disordered media, we argue that the time-dependence in both directions can arise due to structural disorder, such as axonal beads in the longitudinal direction, and the random packing geometry of fibers within a bundle in the transverse direction. These time-dependent effects extend beyond a simple picture of Gaussian compartments, and may lead to novel markers that are specific to neuronal fiber geometry at the micrometer scale.
Related Links	http://europepmc.org/articles/pmc4803645?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803645/pdf
Ending Page	427
Page Count	14
Starting Page	414
ISSN	10538119
DOI	10.1016/j.neuroimage.2016.01.018
Journal	NeuroImage
Volume Number	129
Language	English
Publisher	Elsevier BV
Publisher Date	2016-04-01
Access Restriction	Open
Subject Keyword	Journal: NeuroImage Diffusion Tensor Imaging Hindered Diffusion Time-dependent Diffusion
Content Type	Text
Resource Type	Article
Subject	Neurology Cognitive Neuroscience

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