NDLI: Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity

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Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity

Content Provider	Scilit
Author	Baldisserotto, Anna Demurtas, Monica Lampronti, Ilaria Moi, Davide Balboni, Gianfranco Vertuani, Silvia Manfredini, Stefano Onnis, Valentina
Copyright Year	2018
Description	Journal: European Journal of Medicinal Chemistry New benzofuranhydrazones 3–12 were easily prepared and assayed for their radical-scavenging ability. Hydrazones 3–12 showed different extent antioxidant activity in DPPH, FRAP and ORAC assays. Good antioxidant activity is related to the number and position of hydroxyl groups on the arylidene moiety. High antioxidant activity is showed by the 2-hydroxy-4-(diethylamino)benzylidene derivative 11. Furthermore, hydrazones 3–12 showed photoprotective capacities with satisfactory in vitro SPF as compared to the commercial PBSA sunscreen filter. The antiproliferative effects of the hydrazones 3–12 was tested on erythroleukemia K562 and Colo-38 melanoma human cells. All the compounds showed growth inhibition in the micromolar to sub micromolar concentration range. If taken together these results points to benzofuran hydrazones as potential multifunctional molecules especially in the treatment of neoplastic diseases being the good antioxidant properties of 5, 7 and 11 correlated to their high antiproliferative activity.
Related Links	https://iris.unica.it/retrieve/handle/11584/248598/300490/EJMC_Benzofuranoidrazoni_2018.pdf
Ending Page	125
Page Count	8
Starting Page	118
ISSN	02235234
e-ISSN	17683254
DOI	10.1016/j.ejmech.2018.07.001
Journal	European Journal of Medicinal Chemistry
Volume Number	156
Language	English
Publisher	Elsevier BV
Publisher Date	2018-08-01
Access Restriction	Open
Subject Keyword	Journal: European Journal of Medicinal Chemistry Medicinal Chemistry Benzofuran Hydrazones Polyhydroxylated Compounds Antioxidant Activity Photoprotective Agents Antiproliferative Activity
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Pharmacology

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