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Effect of Pioglitazone on Cardiometabolic Risk in Patients With Obstructive Sleep Apnea
| Content Provider | Scilit |
|---|---|
| Author | Liu, Alice Abbasi, Fahim Kim, Sun H. Ariel, Danit Lamendola, Cindy Cardell, James Xu, Shiming Patel, Shailja Tomasso, Vanessa Mojaddidi, Hafasa Grove, Kaylene Tsao, Philip S. Kushida, Clete A. Reaven, Gerald M. |
| Copyright Year | 2017 |
| Description | Journal: The American journal of cardiology Prevalence of insulin resistance is increased in patients with obstructive sleep apnea (OSA). Because insulin resistance is an independent predictor of cardiovascular disease (CVD), this study was initiated to see if pioglitazone administration would improve insulin sensitivity and thereby decrease risk of CVD in overweight/obese, nondiabetic, insulin-resistant patients with untreated OSA. Patients (n = 30) were administered pioglitazone (45 mg/day) for 8 weeks, and measurements were made before and after intervention of insulin action (insulin-mediated glucose uptake by the insulin suppression test), C-reactive protein, lipid/lipoprotein profile, and gene expression profile of periumbilical subcutaneous fat tissue. Insulin sensitivity increased 31% (p <0.001) among pioglitazone-treated subjects, associated with a decrease in C-reactive protein concentration (p ≤0.001), a decrease in plasma triglyceride, and increase in high-density lipoprotein cholesterol concentrations (p ≤0.001), accompanied by significant changes in apolipoprotein A1 and B concentrations and lipoprotein subclasses known to decrease CVD risk. In addition, subcutaneous adipose tissue gene expression profile showed a 1.6-fold (p <0.01) increase in GLUT4 expression and decreased expression in 5 of 9 inflammatory genes (p <0.05). In conclusion, enhanced insulin sensitivity can significantly decrease multiple cardiometabolic risk factors in patients with untreated OSA, consistent with the view that coexisting insulin resistance plays an important role in the association between OSA and increased risk of CVD. |
| Related Links | http://europepmc.org/articles/pmc5386603?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386603/pdf http://www.ajconline.org/article/S0002914917300590/pdf |
| Ending Page | 1210 |
| Page Count | 6 |
| Starting Page | 1205 |
| ISSN | 00029149 |
| e-ISSN | 18791913 |
| DOI | 10.1016/j.amjcard.2016.12.034 |
| Journal | The American journal of cardiology |
| Issue Number | 8 |
| Volume Number | 119 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-01-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: The American journal of cardiology Respiratory System Obstructive Sleep Apnea Cardio-metabolic Risk Insulin Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
