Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

Content Provider	Scilit
Author	Aceves, Seema S. King, Eileen Collins, Margaret H. Yang, Guang-Yu Capocelli, Kelley E. Abonia, J. Pablo Atkins, Dan Bonis, Peter A. Carpenter, Christina L. Dellon, Evan S. Eby, Michael D. Falk, Gary W. Gonsalves, Nirmala Gupta, Sandeep K. Hirano, Ikuo Kocher, Kendra Krischer, Jeffrey P. Leung, John Lipscomb, Jessi Menard-Katcher, Paul Mukkada, Vincent A. Pan, Zhaoxing Spergel, Jonathan M. Sun, Qin Wershil, Barry K. Rothenberg, Marc E. Furuta, Glenn T. Arrington, Ashley Bailey, Jeanie Besse, John Burke, Deirdre Covington, Jacquelyn DeMarschall, Maureen Dohil, Ranjan Dubner, Allison Foote, Heather Guan, Shaobo Hurnton, Alicia Kodroff, Ellyn Kuhl, Jonathan Kyle, Shay Lewis, Megan Mack, Denise McGee, Sarah Mingler, Melissa Moist, Susan Muir, Amanda Poppendeck, Heidi Putnam, Philip Reidy, Cathy Rudman-Spergel, Amanda K. Sable, Kathleen Scott, Melissa Strobel, Mary Jo Thompson, Katherine Wechsler, Joshua
Copyright Year	2018
Description	Journal: The Journal of Allergy and Clinical Immunology Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P < .001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P < .001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P < .001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) showed a weak correlation with proximal, but not distal, peak eosinophil counts and features and architectural tissue changes on the EoE Histology Scoring System (P < .05). Parents of children with EoE aged 3 to 18 years accurately reflected their children's disease symptoms and QOL. Self- and parent-reported symptoms correlate with proximal esophageal histology. Our data suggest that parental report in young children can function as an adequate marker for self-reported symptoms and that self-reported symptoms can reflect changes in tissue histology in the proximal esophagus. These findings should be considered during clinical trials for drug development.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035777/pdf http://www.jacionline.org/article/S0091674918307747/pdf
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2018.05.014
Journal	The Journal of Allergy and Clinical Immunology
Issue Number	1
Volume Number	142
Language	English
Publisher	Elsevier BV
Publisher Date	2018-05-28
Access Restriction	Open
Subject Keyword	Journal: The Journal of Allergy and Clinical Immunology Eosinophilic Esophagitis Eosinophilic Oesophagitis Consortium of Eosinophilic Gastrointestinal Disease Researchers Patient-reported Outcomes Pediatric Eosinophilic Esophagitis Symptom Score Version 2 Pediatric Qol Eoe Module Quality of Life Eoe Histology Scoring System Gastroesophageal Reflux Disease Interquartile Range Outcomes Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology