NDLI: DNA repair fidelity in stem cell maintenance, health, and disease

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DNA repair fidelity in stem cell maintenance, health, and disease

Content Provider	Scilit
Author	Mani, Chinnadurai Reddy, P. Hemachandra Palle, Komaraiah
Copyright Year	2019
Description	Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Stem cells are a sub population of cell types that form the foundation of our body, and have the potential to replicate, replenish and repair limitlessly to maintain the tissue and organ homeostasis. Increased lifetime and frequent replication set them vulnerable for both exogenous and endogenous agents-induced DNA damage compared to normal cells. To counter these damages and preserve genetic information, stem cells have evolved with various DNA damage response and repair mechanisms. Furthermore, upon experiencing irreparable DNA damage, stem cells mostly prefer early senescence or apoptosis to avoid the accumulation of damages. However, the failure of these mechanisms leads to various diseases, including cancer. Especially, given the importance of stem cells in early development, DNA repair deficiency in stem cells leads to various disabilities like developmental delay, premature aging, sensitivity to DNA damaging agents, degenerative diseases, etc. In this review, we have summarized the recent update about how DNA repair mechanisms are regulated in stem cells and their association with disease progression and pathogenesis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935429/pdf
ISSN	09254439
e-ISSN	1879260X
DOI	10.1016/j.bbadis.2019.03.017
Journal	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Issue Number	4
Volume Number	1866
Language	English
Publisher	Elsevier BV
Publisher Date	2019-04-04
Access Restriction	Open
Subject Keyword	Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Dna Damage and Repair Stem Cells Gene Therapy
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Molecular Medicine

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