ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo

Content Provider	Scilit
Author	Liu, Zhi Qiao, Jing Nagy, Tamas Xiong, May P.
Copyright Year	2018
Description	Journal: Journal of Controlled Release Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term subcutaneous administration of Deferoxamine (DFO) is currently clinically-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates. Serum ferritin levels and iron concentrations in major organs of IO mice decreased following treatment with rNG-DFO, and fecal elimination of iron-bound chelates increased compared to free DFO. Furthermore, rNG-DFO decreased iron mediated oxidative stress levels in vitro and reduced iron-mediated inflammation in the liver of IO mice. The study confirms that ROS-responsive nanogels may serve as a promising alternative to DFO for safer and more efficient iron chelation therapy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035766/pdf
Ending Page	93
Page Count	10
Starting Page	84
ISSN	01683659
e-ISSN	18734995
DOI	10.1016/j.jconrel.2018.05.025
Journal	Journal of Controlled Release
Volume Number	283
Language	English
Publisher	Elsevier BV
Publisher Date	2018-08-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Controlled Release Reactive Oxygen Species (ros) Chelation Therapy Iron Overload (io) Deferoxamine (dfo)
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science