NDLI: Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

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Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

Content Provider	Scilit
Author	Salminen, Tiina S. Oliveira, Marcos T. Cannino, Giuseppe Lillsunde, Päivi Jacobs, Howard T. Kaguni, Laurie S.
Copyright Year	2017
Description	Journal: Mitochondrion We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype.
Related Links	https://repositorio.unesp.br/bitstream/11449/162831/1/WOS000402023900011.pdf
Ending Page	83
Page Count	9
Starting Page	75
ISSN	15677249
e-ISSN	18728278
DOI	10.1016/j.mito.2017.02.001
Journal	Mitochondrion
Volume Number	34
Language	English
Publisher	Elsevier BV
Publisher Date	2017-05-01
Access Restriction	Open
Subject Keyword	Journal: Mitochondrion Mitochondrial Dna
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine

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