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A dosimetric evaluation of IGART strategies for cervix cancer treatment
| Content Provider | Scilit |
|---|---|
| Author | O’Reilly, Frederika H. J. Shaw, William |
| Copyright Year | 2016 |
| Description | Journal: Physica Medica Purpose Image guided adaptive radiotherapy (IGART) strategies can be used to include the temporal aspects of radiotherapy treatment. A dosimetric evaluation of on- and off-line adaptive strategies are done in this study. Methods A library of equivalent uniform dose (EUD)-based Intensity Modulated Radiotherapy Treatment plans with incrementally increasing clinical target volume (CTV)-to-planning target volume (PTV) margins were developed for 10 patients. Utilizing daily computed tomography (CT) images an on-line strategy using a margin-of-the-day (MOD) concept that selects the best plan from the library was employed. This was compared to an off-line strategy with full analysis of accumulated dose between fractions where dosimetric deviations from the treatment intent triggered plan adaptation. A fixed margin treatment approach was used as benchmark. Results Using fixed margins of <15mm lead to under-dosages of more than 5Gy in total delivered dose. The average CTV EUD for the off-line and on-line strategy was 50.0±5.0Gy and 50.4±2.0Gy respectively and OAR doses were comparable. Conclusion A fixed margin treatment approach yields a significant probability of CTV under-dosage. Using EUD dose metrics CTV coverage can be restored in both the off-line and on-line adaptive strategies at acceptable OAR dose levels. Considering the workload and time on the treatment machine, the off-line strategy proves to be sufficient and more practical. |
| Related Links | http://www.physicamedica.com/article/S1120179716301156/pdf |
| Ending Page | 1367 |
| Page Count | 8 |
| Starting Page | 1360 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2016.06.003 |
| Journal | Physica Medica |
| Issue Number | 10 |
| Volume Number | 32 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-06-11 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Radiology, Nuclear Medicine and Imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
