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Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles – Composition-dependent skin penetration enhancement of a dye probe and biocompatibility
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Nan Said, André Wischke, Christian Kral, Vivian Brodwolf, Robert Volz, Pierre Boreham, Alexander Gerecke, Christian Li, Wenzhong Neffe, Axel T. Kleuser, Burkhard Alexiev, Ulrike Lendlein, Andreas Schäfer-Korting, Monika |
| Copyright Year | 2017 |
| Description | Journal: European Journal of Pharmaceutics and Biopharmaceutics Nanoparticles can improve topical drug delivery: size, surface properties and flexibility of polymer nanoparticles are defining its interaction with the skin. Only few studies have explored skin penetration for one series of structurally related polymer particles with systematic alteration of material composition. Here, a series of rigid poly[acrylonitrile-co-(N-vinyl pyrrolidone)] model nanoparticles stably loaded with Nile Red or Rhodamin B, respectively, was comprehensively studied for biocompatibility and functionality. Surface properties were altered by varying the molar content of hydrophilic NVP from 0 to 24.1% and particle size ranged from 35 to 244nm. Whereas irritancy and genotoxicity were not revealed, lipophilic and hydrophilic nanoparticles taken up by keratinocytes affected cell viability. Skin absorption of the particles into viable skin ex vivo was studied using Nile Red as fluorescent probe. Whilst an intact stratum corneum efficiently prevented penetration, almost complete removal of the horny layer allowed nanoparticles of smaller size and hydrophilic particles to penetrate into viable epidermis and dermis. Hence, systematic variations of nanoparticle properties allows gaining insights into critical criteria for biocompatibility and functionality of novel nanocarriers for topical drug delivery and risks associated with environmental exposure. |
| Related Links | http://www.hzg.de/imperia/md/content/gkss/zentrale_einrichtungen/bibliothek/journals/2016/zhang_35120.pdf |
| Ending Page | 75 |
| Page Count | 10 |
| Starting Page | 66 |
| ISSN | 09396411 |
| DOI | 10.1016/j.ejpb.2016.10.019 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume Number | 116 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: European Journal of Pharmaceutics and Biopharmaceutics Pharmacology and Pharmacy Biocompatibility Testing Drug Delivery Systems Poly[acrylonitrile-co-(n-vinyl Pyrrolidone)] |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biotechnology Pharmaceutical Science |
