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Idiopathic Pulmonary Fibrosis
| Content Provider | Scilit |
|---|---|
| Author | Salisbury, Margaret L. Xia, Meng Zhou, Yueren Murray, Susan Tayob, Nabihah Brown, Kevin K. Wells, Athol U. Schmidt, Shelley L. Martinez, Fernando J. Flaherty, Kevin R. |
| Copyright Year | 2016 |
| Description | Journal: Chest Idiopathic pulmonary fibrosis is a progressive lung disease with variable course. The Gender-Age-Physiology (GAP) Index and staging system uses clinical variables to stage mortality risk. It is unknown whether clinical staging predicts future decline in pulmonary function. We assessed whether the GAP stage predicts future pulmonary function decline and whether interval pulmonary function change predicts mortality after accounting for stage. Patients with idiopathic pulmonary fibrosis (N = 657) were identified retrospectively at three tertiary referral centers, and baseline GAP stages were assessed. Mixed models were used to describe average trajectories of FVC and diffusing capacity of the lung for carbon monoxide (Dlco). Multivariable Cox proportional hazards models were used to assess whether declines in pulmonary function ≥ 10% in 6 months predict mortality after accounting for GAP stage. Over a 2-year period, GAP stage was not associated with differences in yearly lung function decline. After accounting for stage, a 10% decrease in FVC or Dlco over 6 months independently predicted death or transplantation (FVC hazard ratio, 1.37; Dlco hazard ratio, 1.30; both, P ≤ .03). Patients with GAP stage 2 with declining pulmonary function experienced a survival profile similar to patients with GAP stage 3, with 1-year event-free survival of 59.3% (95% CI, 49.4-67.8) vs 56.9% (95% CI, 42.2-69.1). Baseline GAP stage predicted death or lung transplantation but not the rate of future pulmonary function decline. After accounting for GAP stage, a decline of ≥ 10% over 6 months independently predicted death or lung transplantation. |
| Related Links | http://europepmc.org/articles/pmc4944785?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944785/pdf |
| Ending Page | 498 |
| Page Count | 8 |
| Starting Page | 491 |
| ISSN | 00123692 |
| e-ISSN | 19313543 |
| DOI | 10.1378/chest.15-0530 |
| Journal | Chest |
| Issue Number | 2 |
| Volume Number | 149 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chest Respiratory System |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Critical Care and Intensive Care Medicine Cardiology and Cardiovascular Medicine |
