Detection of Reduced Retinal Vessel Density in Eyes with Geographic Atrophy Secondary to Age-Related Macular Degeneration Using Projection-Resolved Optical Coherence Tomography Angiography

Content Provider	Scilit
Author	You, Qi Sheng Wang, Jie Guo, Yukun Flaxel, Christina J. Hwang, Thomas S. Huang, David Jia, Yali Bailey, Steven T.
Copyright Year	2019
Description	Journal: American Journal of Ophthalmology Purpose To compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes by using projection-resolved optical coherence tomography angiography (PR-OCTA). Design Prospective cross-sectional study. Methods Study participants underwent macular 3- × 3-mm OCTA scans with spectral domain OCTA. Reflectance-compensated retinal vessel densities were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Quantitative analysis using normalized deviation compared the retinal vessel density in GA regions, 500-μm GA rim regions, and non-GA regions to similar macular locations in control eyes. Results Ten eyes with GA and 10 control eyes were studied. Eyes with GA had significantly lower vessel density in the SVC (54.8 ± 2.4% vs. 60.8 ± 3.1%; P < 0.001), ICP (34.0 ± 1.5% vs. 37.3 ± 1.7%; P = 0.003) and DCP (24.4 ± 2.3% vs. 28.0 ± 2.3%; P < 0.001) than control eyes. Retinal vessel density within the GA region decreased significantly in SVC, ICP, and DCP. Retinal vessel density in the GA rim region decreased in SVC and ICP but not in DCP. The non-GA region did not significantly deviate from normal controls. Eyes with GA had significantly reduced photoreceptor layer thickness; but similar nerve fiber layer, ganglion cell complex, inner nuclear layer, and outer plexiform layer thickness. Conclusions Eyes with GA have reduced retinal vessel density in SVC, ICP, and DCP compared to those in controls. Loss is greatest within regions of GA. Vessel density may be more sensitive than retinal layer thickness measurement in the detection of inner retinal change in eyes with GA.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911625/pdf http://www.ajo.com/article/S0002939419304611/pdf
Ending Page	212
Page Count	7
Starting Page	206
ISSN	00029394
e-ISSN	18791891
DOI	10.1016/j.ajo.2019.09.004
Journal	American Journal of Ophthalmology
Volume Number	209
Language	English
Publisher	Elsevier BV
Publisher Date	2019-09-14
Access Restriction	Open
Subject Keyword	Journal: American Journal of Ophthalmology Age-related Macular Degeneration Geographic Atrophy Optical Coherence Tomography
Content Type	Text
Resource Type	Article
Subject	Ophthalmology