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Extraction and characterization of collagen from Antarctic and Sub-Antarctic squid and its potential application in hybrid scaffolds for tissue engineering
| Content Provider | Scilit |
|---|---|
| Author | Coelho, Rui C. G. Marques, Ana L. P. Oliveira, Sara M. Diogo, Gabriela S. Pirraco, Rogério P. Moreira-Silva, Joana Xavier, José C. Reis, Rui L. Silva, Tiago H. Mano, João F. |
| Copyright Year | 2017 |
| Description | Journal: Materials Science and Engineering: C Collagen is the most abundant protein found in mammals and it exhibits a low immunogenicity, high biocompatibility and biodegradability when compared with others natural polymers. For this reason, it has been explored for the development of biologically instructive biomaterials with applications for tissue substitution and regeneration. Marine origin collagen has been pursued as an alternative to the more common bovine and porcine origins. This study focused on squid (Teuthoidea: Cephalopoda), particularly the Antarctic squid Kondakovia longimana and the Sub-Antarctic squid Illex argentinus as potential collagen sources. In this study, collagen has been isolated from the skins of the squids using acid-based and pepsin-based protocols, with the higher yield being obtained from I. argentinus in the presence of pepsin. The produced collagen has been characterized in terms of physicochemical properties, evidencing an amino acid profile similar to the one of calf collagen, but exhibiting a less preserved structure, with hydrolyzed portions and a lower melting temperature. Pepsin-soluble collagen isolated from I. argentinus was selected for further evaluation of biomedical potential, exploring its incorporation on poly-ε-caprolactone (PCL) 3D printed scaffolds for the development of hybrid scaffolds for tissue engineering, exhibiting hierarchical features. |
| Related Links | http://repositorium.sdum.uminho.pt/bitstream/1822/46892/1/19057-Coelho2017_SquidCollagenHybridScaffolds.pdf |
| Ending Page | 795 |
| Page Count | 9 |
| Starting Page | 787 |
| ISSN | 09284931 |
| DOI | 10.1016/j.msec.2017.04.122 |
| Journal | Materials Science and Engineering: C |
| Volume Number | 78 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Materials Science and Engineering: C Hierarchical Scaffolds Marine Biomaterials Three Dimensional Hybrid Scaffolds |
| Content Type | Text |
| Resource Type | Article |
| Subject | Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering |
