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Effects of ovariectomy on periodontal tissues following tooth replantation
| Content Provider | Scilit |
|---|---|
| Author | Marão, Heloisa Fonseca Mao, Jeremy J. Casatti, Cláudio Aparecido Coelho, Paulo G. Ervolino, Edilson Zhou, Jian Silva, Vanessa Ferreira da Panzarini, Sônia Regina |
| Copyright Year | 2016 |
| Description | Journal: Archives of oral biology The aim of the study was to analyze the effects of ovariectomy on periodontal tissues following immediate tooth replantation by histomorphometric, immunohistochemistry, and μCT analysis. Eighty wistar rats (Rattus norvegicus albinos) with normal estrous cycles were randomly divided into two groups: ovariectomized (OVX) and Sham. Two months after surgery, the rats' upper right incisor was extracted followed by immediate reimplantation. The animals were sacrificed after 28, 45, and 60 days healing time. Histomorphometric and immunohistochemical analysis were performed by evaluation of PCNA and TRAP straining. The periodontal ligament was reinserted into the bone and cementum in the both groups. The immunohistochemical analysis revealed PCNA positive cells on the periodontal ligament in both groups at 28 days. Root resorption was noted at 45 days with immunoreactive cells for TRAP present in bone and tooth surface however no statistical differences between the groups were noticed. Histomorphometric analysis showed significant difference between groups in the periodontal ligament and root resorption parameters for the sub-items: intensity of chronic inflammatory infiltrate at 60 days (p<0.01), the organization of the periodontal ligament at 28 days (p<0.05), depth of root resorption at 45 days (p<0.05) and at 60 days (p<0.001). The μCT analysis showed multiple areas of bone resorption in association with OVX at 28 and 60 days with no significant differences between times in vivo. The ovariectomy did not have significant influence in periodontal tissue parameters following tooth reimplantation. |
| Related Links | https://repositorio.unesp.br/bitstream/11449/172490/1/2-s2.0-84956751843.pdf |
| ISSN | 00039969 |
| e-ISSN | 18791506 |
| DOI | 10.1016/j.archoralbio.2016.01.006 |
| Journal | Archives of oral biology |
| Volume Number | 65 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Archives of oral biology Dentistry and Oral Surgery Immunohistochemistry Tooth Replantation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dentistry Cell Biology Otorhinolaryngology |
