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Vascularization of three-dimensional engineered tissues for regenerative medicine applications
| Content Provider | Scilit |
|---|---|
| Author | Kim, Joseph J. Hou, Luqia Huang, Ngan F. |
| Copyright Year | 2016 |
| Description | Journal: Acta biomaterialia Engineering of three-dimensional (3D) tissues is a promising approach for restoring diseased or dysfunctional myocardium with a functional replacement. However, a major bottleneck in this field is the lack of efficient vascularization strategies, because tissue constructs produced in vitro require a constant flow of oxygen and nutrients to maintain viability and functionality. Compared to angiogenic cell therapy and growth factor treatment, bioengineering approaches such as spatial micropatterning, integration of sacrificial materials, tissue decellularization, and 3D bioprinting enable the generation of more precisely controllable neovessel formation. In this review, we summarize the state-of-the-art approaches to develop 3D tissue engineered constructs with vasculature, and demonstrate how some of these techniques have been applied towards regenerative medicine for treatment of heart failure. |
| Related Links | http://europepmc.org/articles/pmc4969172?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969172/pdf |
| Ending Page | 26 |
| Page Count | 10 |
| Starting Page | 17 |
| ISSN | 17427061 |
| e-ISSN | 18787568 |
| DOI | 10.1016/j.actbio.2016.06.001 |
| Journal | Acta biomaterialia |
| Volume Number | 41 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-06-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta biomaterialia Cardiac Engineering Tissue Engineering Extracellular Matrix |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology |
