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Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling
| Content Provider | Scilit |
|---|---|
| Author | Menezes, Sharleen V. Sahni, Sumit Kovacevic, Zaklina Richardson, Des R. |
| Copyright Year | 2017 |
| Description | Journal: Journal of Biological Chemistry The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells. Recent findings have demonstrated that NDRG1 inhibits the ErbB family of receptors, which function as key inducers of carcinogenesis. NDRG1 attenuates ErbB signaling by inhibiting formation of epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER2) and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degradation. Understanding the complex interplay between NDRG1, iron, and ErbB signaling is vital for identifying novel, more effective targets for cancer therapy. |
| Related Links | http://www.jbc.org/content/292/31/12772.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546018/pdf http://www.jbc.org/article/S0021925820400493/pdf |
| Ending Page | 12782 |
| Page Count | 11 |
| Starting Page | 12772 |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| DOI | 10.1074/jbc.r117.776393 |
| Journal | Journal of Biological Chemistry |
| Issue Number | 31 |
| Volume Number | 292 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biological Chemistry Biochemistry and Molecular Biology Cancer Therapy Cell Signaling Epidermal Growth Factor Receptor (egfr) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
