Loading...
Please wait, while we are loading the content...
Similar Documents
Histomorphological and biochemical properties of plantar soft tissue in diabetes
| Content Provider | Scilit |
|---|---|
| Author | Wang, Yak-Nam Lee, Kara Shofer, Jane B. Ledoux, William R. |
| Copyright Year | 2017 |
| Description | Journal: The Foot Diabetes results in pathophysiological changes, leading to tissue that is unable to withstand and adapt to the same loads, resulting in breakdown. Certain locations are more susceptible to breakdown, yet differences between locations are largely not well understood. The authors performed a histological and biochemical analysis of isolated plantar adipose tissue at six relevant locations. Tissue from six plantar locations (hallux, first, third and fifth metatarsal heads, lateral midfoot and calcaneus) was taken from fresh cadaveric feet of older diabetic and older non-diabetic intact donors. Histomorphological and biochemical analysis of isolated plantar tissue from both diabetic and non-diabetic feet at six relevant locations was performed. The main differences found between diabetic and non-diabetic tissue were in the thickness of the septal walls and the elastin content. Diabetic tissue had significantly thicker septal walls and an increased elastin concentration. When comparing the calcaneus to other locations, although there were no differences found in the thickness of the septal walls of diabetic tissue, elastin content was lower in the calcaneous tissue compared to the non-calcaneus sites. Modifications in the structural and biochemical properties could translate to changes in the mechanical properties. This information could lead to an understanding of how the structural and biochemical changes result in an increase in susceptibility of tissue to breakdown with load at the different locations of the foot. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937986/pdf |
| Ending Page | 6 |
| Page Count | 6 |
| Starting Page | 1 |
| ISSN | 09582592 |
| e-ISSN | 15322963 |
| DOI | 10.1016/j.foot.2017.06.001 |
| Journal | The Foot |
| Volume Number | 33 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Foot Diabetic Foot Ulcer Histomorphological Plantar Soft Tissue |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Podiatry |
