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Association Between Multi-frequency Phase Angle and Survival in Patients With Advanced Cancer
| Content Provider | Scilit |
|---|---|
| Author | Hui, David Dev, Rony Pimental, Lindsay Park, Minjeong Cerana, Maria A. Liu, Diane Bruera, Eduardo |
| Copyright Year | 2016 |
| Description | Journal: Journal of Pain and Symptom Management Context The ability to predict survival accurately has implications in clinical decision making. Objectives We determined the association of phase angle obtained from multi-frequency bioelectric impedance analysis with overall survival in patients with advanced cancer. Methods We included consecutive patients with advanced cancer who had an outpatient palliative care consultation. Multi-frequency bioelectric impedance analysis assessed phase angle at three different frequencies (5/50/250 kHz) on each hemibody (right/left). Survival analysis was conducted using the Kaplan-Meier method, log-rank test, and multivariate Cox regression analysis. Results Among 366 patients, the median overall survival was 250 days (95% confidence interval 191–303 days). The mean phase angle for 5, 50, and 250 kHz were 2.2°, 4.4°, and 4.2° on the right and 2.0°, 4.2° and 4.1° on the left, respectively. For all six phase angles, a lower value was significantly associated with a poorer overall survival (P < 0.001). After adjusting for cancer type, performance status, weight loss, and inflammatory markers, phase angle remained independently associated with overall survival (hazard ratio 0.85 per degree increase, 95% confidence interval 0.72–0.99; P = 0.048). Conclusion Phase angle represents a novel objective prognostic factor in outpatient palliative cancer care setting, regardless of frequency and body sides. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337125/pdf http://www.jpsmjournal.com/article/S0885392416312003/pdf |
| Ending Page | 577 |
| Page Count | 7 |
| Starting Page | 571 |
| ISSN | 08853924 |
| e-ISSN | 18736513 |
| DOI | 10.1016/j.jpainsymman.2016.09.016 |
| Journal | Journal of Pain and Symptom Management |
| Issue Number | 3 |
| Volume Number | 53 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-12-30 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Pain and Symptom Management Endocrinology and Metabolism Electric Impedance Palliative Care |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nursing Neurology (clinical) Anesthesiology and Pain Medicine |
