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Testing Different Combinations of Acoustic Pressure and Doses of Quinolinic Acid for Induction of Focal Neuron Loss in Mice Using Transcranial Low-Intensity Focused Ultrasound
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Yanrong Liao, Chengde Qu, Haibo Huang, Siqin Jiang, Hong Zhou, Haiyan Abrams, Emily Habte, Frezghi G. Yuan, Li Bertram, Edward H. Lee, Kevin S. Pauly, Kim Butts Buckmaster, Paul S. Wintermark, Max |
| Copyright Year | 2019 |
| Description | Journal: Ultrasound in Medicine & Biology The goal of this study was to test different combinations of acoustic pressure and doses of quinolinic acid (QA) for producing a focal neuronal lesion in the murine hippocampus without causing unwanted damage to adjacent brain structures. Sixty male CD-1 mice were divided into 12 groups that underwent magnetic resonance-guided focused ultrasound at high (0.67 MPa), medium (0.5 MPa) and low (0.33 MPa) acoustic peak negative pressures and received QA at high (0.012 mmol), medium (0.006 mmol) and low (0.003 mmol) dosages. Neuronal loss occurred only when magnetic resonance-guided focused ultrasound with adequate acoustic power (0.67 or 0.5 MPa) was combined with QA. The animals subjected to the highest acoustic power had larger lesions than those treated with medium acoustic power, but two mice had evidence of bleeding. When the intermediate acoustic power was used, medium andhigh dosages of QA produced lesions larger than those produced by the low dosage. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289648/pdf |
| Ending Page | 136 |
| Page Count | 8 |
| Starting Page | 129 |
| ISSN | 03015629 |
| e-ISSN | 1879291X |
| DOI | 10.1016/j.ultrasmedbio.2018.08.023 |
| Journal | Ultrasound in Medicine & Biology |
| Issue Number | 1 |
| Volume Number | 45 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Ultrasound in Medicine & Biology Blood–brain Barrier Magnetic Resonance-guided Focused Ultrasound Transcranial Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Acoustics and Ultrasonics Biophysics Radiological and Ultrasound Technology |
