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Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum
| Content Provider | Scilit |
|---|---|
| Author | Balla, Tamas Sengupta, Nivedita Kim, Yeun Ju |
| Copyright Year | 2019 |
| Description | Journal: Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids Structural lipids are mostly synthesized in the endoplasmic reticulum (ER), from which they are actively transported to the membranes of other organelles. Lipids can leave the ER through vesicular trafficking or non-vesicular lipid transfer and, curiously, both processes can be regulated either by the transported lipid cargos themselves or by different secondary lipid species. For most structural lipids, transport out of the ER membrane is a key regulatory component controlling their synthesis. Distribution of the lipids between the two leaflets of the ER bilayer or between the ER and other membranes is also critical for maintaining the unique membrane properties of each cellular organelle. How cells integrate these processes within the ER depends on fine spatial segregation of the molecular components and intricate metabolic channeling, both of which we are only beginning to understand. This review will summarize some of these complex processes and attempt to identify the organizing principles that start to emerge. This article is part of a Special Issue entitled Endoplasmic reticulum platforms for lipid dynamics edited by Shamshad Cockcroft and Christopher Stefan. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858525/pdf |
| ISSN | 13881981 |
| e-ISSN | 18792618 |
| DOI | 10.1016/j.bbalip.2019.05.005 |
| Journal | Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids |
| Issue Number | 1 |
| Volume Number | 1865 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2019-05-18 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids Endoplasmic Reticulum Phosphatidylinositol Phosphatidylserine Phosphatidylcholine Lipid Transfer Protein Membrane Contact Sites Non-vesicular Lipid Transfer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
