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Kinetics of charged antibiotic penetration into human intervertebral discs: A numerical study
| Content Provider | Scilit |
|---|---|
| Author | Zhu, Qiaoqiao Gao, Xin Li, Na Gu, Weiyong Eismont, Frank Brown, Mark D. |
| Copyright Year | 2016 |
| Description | Journal: Journal of Biomechanics Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from z=+2 (positively charged) to z=−2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections. |
| Related Links | http://europepmc.org/articles/pmc5056146?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056146/pdf |
| Ending Page | 3084 |
| Page Count | 6 |
| Starting Page | 3079 |
| ISSN | 00219290 |
| e-ISSN | 18732380 |
| DOI | 10.1016/j.jbiomech.2016.07.012 |
| Journal | Journal of Biomechanics |
| Issue Number | 13 |
| Volume Number | 49 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-07-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biomechanics Intervertebral Disc Antibiotic Penetration Transport Phenomena Mixture Theory Finite Element Analysis Disc Infections |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Rehabilitation Biophysics Sports Science Biomedical Engineering |
